Spa areas are resplendent in mosaic and marble and are ultimate expressions of Versace's contemporary take on Classical beauty and luxury. Over two and a half million marble and glass mosaic tiles feature in the spa reception and wet areas, with Versace's Trésor de la Mer print rendered in two different mosaic color variations. The chrysanthemum flower features throughout the spa areas, both as decorative mosaic, chandeliers, and flower arrangements, as well as being served as chrysanthemum tea.

Rejuvenating treatments and massages are exclusively formulated using cosmeceutical spa products from advanced Italian brand MISULA with organic raw ingredients grown in the protected Pollino National Park in southern Italy, combined with sculpting rituals that embrace the Mediterranean philosophy of treating the body's inner and outer wellness needs. MISULA offers a holistic integrative approach to skin care, with treatments formulated exclusively for Palazzo Versace Macau. Each treatment is designed with three goals in mind: to encourage people to celebrate their uniqueness, to put genuine wellness before abstract ideas of beauty, and to prioritize health with herbal infusions and superfoods that support the body's inner wellbeing, allowing its beauty to truly shine on the outside.